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Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Published by Universitas Brawijaya
ISSN : 20875517     EISSN : 25274376     DOI : -
Core Subject : Agriculture, Social,
Agriculture, Biological Sciences & Forestry Environmental Science
The Journal of Tropical Life Science (JTLS) provides publication of full-length papers, short communication and review articles describing of new finding or theory in living system, cells and molecular level in tropical life science and related areas. The journal publishes articles that report novel findings of wide Tropical Life system phenomenon in the areas of biodiversity, agriculture, fisheries, health, husbandry, forestry and environmental technology. JTLS has 1 volume with 3 issues per year.
Arjuna Subject : -
Articles 8 Documents
 1 
Search results for , issue "Vol 5, No 1 (2015)" : 8 Documents clear
Endoglin Expression and the Level of Tgf-Î’ Are Increased In the Placental Tissue and Correlated with Low Fetal Weight in Malaria Infected Mice sasmito, sujarot dwi; Ulfiati, Adilah; Wardana, Ardhian; Nugraheni, Fitriana; Pradiptasari, Nur Fahma; Zulaifa, Zakiyah; Norahmawati, Eviana; Sardjono, Teguh Wahju; Fitri, Loeki Enggar
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

Malaria infection during pregnancy can cause accumulation of infected-red blood cells in placental intervillous space and induces placental tissue inflammation and hypoxia. This condition triggers endoglin expression, and release of soluble endoglin which can interfere TGF-β binding to its receptor. The aim of this study was to investigate the correlation between placental endoglin expression and TGF-β level with low fetal weight (LFW) in malaria-infected mice. Nine pregnant mice infected with Plasmodium berghei on the day 9th post mating (malaria infected group) and eight normal pregnant mice (non-infected group) were used in this study. The mice were sacrificed on the day 18th post mating, and all fetal body weights were measured by analytical scale. Enzyme Link Immunosorbent Assay (ELISA) was done to determine the level of placental TGF-β while immunohistochemical staining was performed to examine endoglin expression in placental tissue. The mean of fetal body weights of malaria infected group was significantly lower than non-infected group (p=0,002), while the expression of placental endoglin in malaria infected group was significantly higher than non-infected group (p=0.003). The level of placental TGF-β in malaria infected group was also higher than non-infected group but the difference was not significant (p=0.064). Pearson correlation test showed that there were significant negative correlations between fetal body weights with the level of placental TGF-β (p=0.017, r=-0.568) and the expression of placental endoglin (p=0.002, r=-0.694). Malaria infection in pregnant mice will increase both TGF- β and endoglin in placenta tissue and correlate with low fetal weight.   
Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods Hikmah, Nuzulul; Shita, Amandia Dewi Permana; Maulana, Hafiedz
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

The prevalence of diabetes increased from year to year. Diabetic animal model was developed to study the pathogenesis and treatment in diabetes. The aim of this study was to determine the profile of diabetic blood glucose levels using a stratified dose streptozotocin (STZ-SD) and multi-low dose streptozotocin (MLD-STZ) induction methods. 27 Wistar rats were divided into three groups, control group, SD-STZ group, and MLD-STZ group. The induction of experimental animal was using the method of SD-STZ and MLD-STZ for 5 consecutive days intraperitoneally. SD-STZ method using stratified dose of 40, 35, 30, 25, and 20 mg/Kg of body weight, while MLD-STZ method using a dose of 20 mg/Kg of body weight for 5 times. The measurement of blood glucose level (BGL) and body weight (BW) in animal was made on 2, 4, 7, and 14 days after STZ induction. The results of this study indicate that the diabetic conditions (BGL ≥ 300 mg/dl) on the SD-STZ induction method was more stable, and no deaths occurred in experimental animals.Keywords: Streptozotocin (STZ), diabetes, blood glucose level (BGL).
Gynura procumbens Ethanolic Extract Promotes Lymphocyte Activation and Regulatory T Cell Generation In Vitro Dwijayanti, Dinia Rizqi; Rifa'i, Muhaimin
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Immune system is a system of biological structures and processes within organism directed to protect against invaded pathogen. Cellular and humoral immune system mediated by immunocompetent cells such as CD4+ T cells, CD8+ T cells, CD4+CD25+ T cells, and B220 cells play important role for maintaining immunological surveillance. The purpose of this study was to determine the effect of ethanolic extract of  G. procumbens leaves (EEGL) on the profile of CD4+ T cells, CD4+CD25+ T cells, and B220+ cells. Splenic cells were isolated from BALB/c mice and cultured in RPMI1640 medium in the presence of EEGL. After 4 days of incubation, cells were harvested, stained with antibodies and analyzed by flow cytometer. The data were analyzed by one-way ANOVA with α= 0.05 and Tukey test using SPSS 16.0 for windows. The results showed that the extract of  G. procumbens could increase proliferation of CD4+CD62L T cell, CD4+CD25+T cells, and B220+ cells compared to the control. Here, we showed the biological effect of G. procumbensas medicinal herb with immunomodulatory activity andthe dose of 0.1 µg/ml and 1.0 µg/ml could promote T cell activation compared to the highest dose of 10 µg/ml. In terestingly, the dose of 10 µg/ml rather promote than inhibit B cell proliferation.
The Pathophysiology and Care of Exercise Related Muscle Cramps Pandey, Abhay Kumar; Pandit, Abha; Pandey, B L
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Cramps are major concerns to competing athletes. The pain alone is not object of treatment as serious metabolic disturbance of electrolyte must gets due consideration. The phenomenon is dealt with some patho-physiological details and relevant clinical information, important as first hand understanding for the sports persons and their care givers.
The Influence of Environmental Factors to The Abundance of Scales (Hemiptera: Diaspididae) Population on Apple Crop Supriadi, Khojin; Mudjiono, Gatot; Abadi, Abdul Latief; Karindah, Sri
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

This research aims to assess the environmental factors that affect the abundance of scales populations on the apple crop. The study was conducted in July 2012 to January 2013. The study was conducted at two sites with different altitude. Bumiaji village's altitude is ±900 m and Tulungrejo village's altitude is ±1,515 m asl. Multiple linear regression analysis was conducted to determine the environmental factors that affect the abundance of scales populations on the apple crop. Based on the results of the regression analysis, air temperature and humidity affect the abundance of scales populations in Binangun while rainfall and long solar radiation have no effect. Scales population abundance of the apple crop in Binangun was influenced by air temperature and humidity one week before. Based on the results of the regression analysis, air temperature, air humidity and rainfall affect the abun dance of scales population in Tulungrejo while long solar radiation has no effect. Scales population abundance ofthe apple crop in Tulungrejo was affected by air temperature two weeks before, while humidity and rainfall were affected one week before. The higher air temperature scales, flea population level will increase. And the higherrelative humidity, scales population levels will increase.
Evaluation Anxiolytic Effect of Methanol Extract of Ceplukan Leaves (Physalis minima L.) in the Elevated Plus Maze Test through IL-6 Level Changes in Ovariectomized Rats Nurfitria, Siti; Permatasari, Nur; Ratnawati, Retty
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

Ceplukan (Physalis minima L.) has long been used to treat various conditions in traditional medicine. This study aims to demonstrate the anxiolytic effects of Methanol Extract of Ceplukan Leaves (MECL) in the Elevated Plus Maze (EPM) test and correlate to IL-6 level of ovariectomized rat brain. Total of 24 Wistar rats were divided into six groups: one normal group, one group of 1 month ovariectomized (ovx), one group of 2 months ovx, three groups of 2 months ovx (each given with MECL 500; 1500 and 2500 mg/kg doses for 1 month). The anxiety-like behavior level was measured by EPM test. After EPM test, the brain was removed to measure level of IL-6 by ELISA. The data were processed and analyzed by one-way ANOVA and Pearson correlation. We found that the MECL-treated rats enter the opened-arm higher than the control rats. It indicates that the MECL-treated rats are less anxious than the control rats. The results also show the decreased of IL-6 level in MECL-treated rats.
Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah D; Angelina, Marissa; Megawati, Megawati; Fajriah, Sofa
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
Flowering and Fruiting Times on Four Species of Annona (Annonaceae) in Purwodadi Botanic Garden Lestari, Dewi Ayu; Sofiah, Siti
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Annona is a genus belongs to Annonaceae family, consisting of numerous species that produce edible fruit.   Four species namely A. glabra, A. montana, A. muricata and A. squamosa collections of Purwodadi Botanic Garden  were recorded for its flowering and fruiting times, since November 2010 to April 2013. The data were scored and complemented with climate data (temperature, rainfall intensity, humidity) then analyzed using multiple linear regression analysis.  The result showed that humidity was the most affected climate factors on the flowering and fruiting times of those species.  Specifically, rainfall intensity (0-550 mm) affected to  Annona muricata, temperature (25,56-28,33 °C) and humidity (66,83-85,02%) to  Annona squamosa, and  humidity to  A. glabra (71,62-85,02% )  and  A. montana (71,62 to 82,94 %) as well. Flowering time of A. glabra occurs three times a year in wet and dry, and fruiting occurs twice a year in the same month. Annona muricata is flowering throughout the year and fruiting twice a year in wet. A. montana and A. squamosa recorded one a year during the wet month.

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